Evaluation Of Iron Sucrose and Oral Iron in Management of Iron Deficiency Anaemia in Pregnancy
Keywords:
Iron sucrose, anemic pregnant women, iron deficiency anemiaAbstract
Objective: To compare intravenous iron sucrose with oral iron in treatment of severe iron deficiency anaemia in pregnant women presenting at Institute of Kidney Disease and Research Centre. The study was carried out in the department of Obstetrics and Gynaecology at Institute of Kidney Disease and Research Centre over a period of six months from 02-02-2010 TO 2-08-2010.
Methodology: 50 cases with proven iron deficiency with Hb ≤7 gm/dl were included in the study. Total iron deficit was calculated using a standard formula. Target haemoglobin was 11 gm %. Iron sucrose was administered by intravenous infusion. Haemoglobin was repeated 1, 2, 3, and 4 weeks after the last dose of Intravenous Iron sucrose.
Results: Anthropometric and biologic data for mothers in i.v. sucrose and oral iron groups was similar. Distribution of cases by economic status showed, 21 patients (42.0%) belonged to lower class, 20 patients (40%) belonged to middle class and 09 patients (18%) were of upper class.) Target haemoglobin levels were achieved in 4 weeks’ time in 19 (76%) patients in iron sucrose group as compared to 08 (32%) of patients in oral iron group. There was significant improvement in the various haematological parameters in iv sucrose group as compared to patients in oral iron group. There were no significant allergic reactions in iv sucrose group.
Conclusion: This study has shown a significant improvement in anaemia in the iron sucrose group. Patients achieved the target of 11 gm %. Intravenous iron therapy is safe, convenient and more effective than oral iron therapy in pregnancy and is well tolerated.
References
Perewusny KG, Huck R, Huck A, Breymann C. Parenteral iron-sucrose complex. Br J Nutr 2002; 88: 3- 10.
Nisar N, White F. Factors affecting utilization of antenatal care among reproductive age group women (15-49 years) in an urban squatter settlement of Karachi. J. Pak Med Assoc 2003; 53: 47-53.
Al-Momen AK, al-Meshari A, al-Nuaim L, Saddique A, Abutalib Z, Khashogi T, et al. Intravenous iron sucrosecomplex in the treatment of iron deficiency anemia during pregnancy. Eur J Obstet Gynecol Reprod Biol 1996; 69: 121-4.
Breymann C. Iron deficiency and anemia in pregnancy: Modern aspects of diagnosis and therapy. Blood Cells Mol Dis 2002; 29: 506-16
Khan MM. Effects of maternal anemia on fetal parameters. J Ayub Med Coll Abbottabad 2001; 13: 38- 41.
Bayoumeu F, Subiran-Buisset C, Baka NE, Legagneur H, Monnier-Barbarino P, Laxenaire MC. Iron therapy in iron deficiency anemia in pregnancy: Intravenous route verses oral route. Am J Obstet Gynecol 2002; 186: 518- 22.
Breymann C; Anemia working group. Current aspects of diagnosis and therapy of iron deficiency anemia in pregnancy. Schweiz Rundsch Med Prax 2001; 90: 1283- 91.
Yaqoob N, Abbasi SM. Nutritional iron deficiency in our population. J. Coll Physicians Surg Pak 2002; 12: 395-7.
Akhtar S, Asif S. Twin gestation antenatal complications and fetal outcome. Pak J. Obstet Gynecol 1996; 9: 23-6.
Christian Breymann.The use of iron sucrose complex for anemia in pregnancy and the post partum period.Semen Hematol ,2006;43(suppl 6):28-31.
Suega K, Dharmayuda TG, Sutarga IM, Bakta IM. Iron- deficiency anemia in pregnant women in Bali, Indonesia: a profile of risk factors and epidemiology. Southeast Asian J Trop Med Public Health 2002; 33: 604-7.
Khosla AH, Dahiya P, Dahiya K. Burden of chronic severe anemia in obstetric
patients in Rural North India. Indian J Med Sci 2002; 56: 222-4.
Khan MM. Effects of maternal anemia on fetal parameters. J Ayub Med Coll Abbottabad 2001; 13: 38- 41.
Bayoumeu F, Subiran-Buisset C, Baka NE, Legagneur H, Monnier-Barbarino P, Laxenaire MC. Iron therapy in iron deficiency anemia in pregnancy: Intravenous route verses oral route. Am J Obstet Gynecol 2002; 186: 518- 22.
Ahmed K, Sadiq I, Yousuf AW. Injectable iron therapy: intramuscular Vsintravenous therapy. Biomedica 2000; 16: 44-7.
Perewusny KG, Huck R, Huck A, Breymann C. Parenteral iron-sucrose complex. Br J Nutr 2002; 88: 3- 10.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
The authors retain the copyright of their article, with first publication rights granted to Medsci Publications.
